Using induced pluripotent stem cell neuronal models to study neurodegenerative diseases.
作者： Xinwen Zhang , Di Hu , Yutong Shang , Xin Qi
DOI: 10.1016/J.BBADIS.2019.03.004
关键词:
摘要: Current application of human induced pluripotent stem cells (hiPSCs) technology in patient-specific models neurodegenerative disorders recapitulate some key phenotypes diseases, representing disease-specific cellular modeling and providing a unique platform for therapeutics development. We review recent efforts toward advancing hiPSCs-derived neuronal cell types highlight their potential use the development more complex vitro diseases by focusing on Alzheimer's disease, Parkinson's Huntington's disease Amyotrophic lateral sclerosis. present evidence from previous works important phenotypic changes various these neurological diseases. also summarize conducting low- high-throughput screening experiments with hiPSCs developing treatment Lastly, we discuss limitations culture system studying alternative strategies to overcome hurdles.
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