Rhodnius prolixus: Modulation of antioxidant defenses by Trypanosoma rangeli

摘要: Trypanosoma rangeli is a protozoan parasite of insects and mammals that challenged by the constant action reactive oxygen species, generated either its own metabolism or through host immune response. The aim this work was to investigate whether T. able modify redox state insect vector, Rhodnius prolixus, modulation such antioxidant enzymes as superoxide dismutase (SOD), catalase, GPx present in midgut insect. We verified R. prolixus fed with blood infected there an increase SOD activity anterior posterior midguts. However, activities related hydrogen peroxide hydroperoxides metabolism, catalase GPx, were decreased relation control group, which only blood. These changes vector led lipid peroxidation thiol oxidation levels tissues. also addition 1 mM GSH meal increased proliferation these parasites 50%. results suggest oxidative stress gut during infection, condition could contribute parasites.