THE PHARMACOLOGY OF THE ISOLATED VEIN RING

摘要: The parallelism between the results of experiments with adrenaline on isolated vein ring and sympathetic stimulation in experimental animal has been taken to justify study action other drugs similar preparations various veins. In doses stated veins used have as follows. Contraction caused by adrenaline, alcohol, barium, calcium, potassium, large amounts chloral hydrate, digitalin, ergamine, ergotoxine, ether some cases, nicotine, pituitrin, strophanthin. Relaxation after small nitrite, carbon dioxide, urethane. No effect atropine, acetyl-choline, pilocarpine, apocodeine, caffeine, theobromine, diuretin, cocaine, magnesium, quinidine, strychnine. Rhythmical movements observed before application any drug, also under influence ergotoxine. Twitches superior vena cava, their duration corresponds that rhythmic recorded unpublished performed 1915 Professor J. A. Gunn rabbit. these a single contraction occupied 3/10 4/10 second. sheep9s cava experiment present series, 1 mm. On tracing represented about seven seconds, twitches observed, all, lines only tracing. These were not demonstrably thicker at top than bottom. Three observers who saw them struck rapidity twitches, which resembled skeletal muscle contractions.