Sister chromatid exchanges—A sensitive assay of agents damaging human chromosomes

作者: Ellen Solomon , Martin Bobrow

DOI: 10.1016/S0027-5107(75)80013-3

关键词:

摘要: Sister chromatid exchange frequencies in human lymphocyte chromosomes are greatly increased by alkylating agents, but ionizing radiation has little if any such effect. Scoring these exchanges may provide a useful technique for exploring the mechanisms of chromosome breakage and repair.

参考文章(13)
James D. Regan, R. B. Setlow, Repair of Chemical Damage to Human DNA Springer, Boston, MA. pp. 151- 170 ,(1973) , 10.1007/978-1-4615-8972-3_6
R. S. K. Chaganti, S. Schonberg, J. German, A manyfold increase in sister chromatid exchanges in Bloom's syndrome lymphocytes. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 71, pp. 4508- 4512 ,(1974) , 10.1073/PNAS.71.11.4508
PAUL PERRY, SHELDON WOLFF, New Giemsa method for the differential staining of sister chromatids Nature. ,vol. 251, pp. 156- 158 ,(1974) , 10.1038/251156A0
S. A. Latt, Sister Chromatid Exchanges, Indices of Human Chromosome Damage and Repair: Detection by Fluorescence and Induction by Mitomycin C Proceedings of the National Academy of Sciences of the United States of America. ,vol. 71, pp. 3162- 3166 ,(1974) , 10.1073/PNAS.71.8.3162
Alan C. Stevenson, Chandrakant Patel, Effects of chlorambucil on human chromosomes. Mutation Research. ,vol. 18, pp. 333- 351 ,(1973) , 10.1016/0027-5107(73)90218-2
S. A. Latt, Microfluorometric detection of deoxyribonucleic acid replication in human metaphase chromosomes. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 70, pp. 3395- 3399 ,(1973) , 10.1073/PNAS.70.12.3395
R. S. Cole, Repair of DNA containing interstrand crosslinks in Escherichia coli: sequential excision and recombination. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 70, pp. 1064- 1068 ,(1973) , 10.1073/PNAS.70.4.1064
Michael A Bender, H. Gaston Griggs, Joel S. Bedford, Recombinational DNA repair and sister chromatid exchanges. Mutation Research. ,vol. 24, pp. 117- 123 ,(1974) , 10.1016/0027-5107(74)90125-0