Cutaneous sympathetic motor rhythms in the decerebrate rat

摘要: Abstract Investigation of rhythmic discharges may provide insights into integrative mechanisms underlying nervous system control effectors. We have previously shown that, in CNS-intact, anesthetized rats, cutaneous sympathetic vasoconstrictor neurones innervating thermoregulatory circulations exhibit a robust rhythmicity the 0.4–1.2-Hz frequency range (T-rhythm). Here we examined whether neural circuitry required to generate this rhythm remained intact decerebrate (at collicular level), paralyzed and artificially ventilated preparations with cervical vagotomy, ligation common carotid arteries pneumothorax. Population activity was recorded from ventral collector nerve (VCN) tail nine animals, while monitoring central respiratory drive. found that feature behaved comparable manner described preparation. Manifest as peaks autospectra, dominant either at ( f ) lung inflation cycle (fLIC), drive (fCRD) or ‘free-run’ T-rhythm range. Through manipulation LIC could alter discharges. show significant relationship between likelihood VCN being neither nor CRD. At 1 Hz: seven animals Hz, zero displayed T-rhythm; 2 two had Hz five T-rhythm. Furthermore, CRD never observed entrain LIC. These experiments demonstrate network generation is located below level neuraxis preparation LIC-related modulation be mediated by spinal (sympathetic) afferents.