Smoking, obesity, alcohol consumption, and the risk of rheumatoid arthritis.

摘要: There is some evidence that sex hormones may influence the incidence of rheumatoid arthritis. Obesity has been found to increase endogenous estrogens, particularly among postmenopausal women. Although association with smoking and alcohol use less clear, we examined relation these three factors arthritis in We conducted a population-based case-control study King County, WA, Group Health Cooperative Puget Sound. compared 349 incident cases 1,457 controls selected by random digit dialing or selection from enrollment files Cooperative. personal interviews collect data on weight, smoking, history, reproductive variables, other demographic variables. Women 20 more pack-years had relative risk 1.5 [95% confidence interval (CI) = 1.0-2.0] never-smokers. Post-menopausal women who averaged than 14 alcoholic drinks per week reduced (relative 0.5; 95% CI 0.2-1.7). highest quartile body mass index 1.4 (95% 1.0-2.0) lowest index.