Schedule-induced polydipsia: a rat model of obsessive-compulsive disorder.
作者： Brian Platt , Chad E. Beyer , Lee E. Schechter , Sharon Rosenzweig‐Lipson
DOI: 10.1002/0471142301.NS0927S43
关键词:
摘要: Obsessive-compulsive disorder (OCD) is difficult to model in animals due the involvement of both mental (obsessions) and physical (compulsions) symptoms. Due limitations using evaluate obsessions, OCD models are limited evaluation compulsive repetitive behaviors animals. Of these, adjunctive offer most value regard predicting efficacy anti-OCD drugs clinic. Adjunctive those that maintained indirectly by variables control another behavior, rather than directly their own typical controlling variables. Schedule-induced polydipsia (SIP) an which rats exhibit exaggerated drinking behavior (polydipsia) when presented with food pellets under a fixed-time schedule. The polydipsic response excessive manifestation normal (drinking), providing face validity model. Furthermore, clinically effective for treatment decrease SIP. This protocol describes rat SIP provides preclinical data OCD.
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