Cervical Cancer: Development of Targeted Therapies Beyond Molecular Pathogenesis
作者： Jayne Knoff , Benjamin Yang , Chien-Fu Hung , T.-C. Wu
DOI: 10.1007/S13669-013-0068-1
关键词:
摘要: It is well-known that the human papillomavirus (HPV) causative agent of cervical cancer. The integration HPV genes into host genome causes upregulation E6 and E7 oncogenes. proteins inactivate degrade tumor suppressors p53 retinoblastoma, respectively, leading to malignant progression. antigens are ideal targets for development therapies cancer precursor lesions because they constitutively expressed in infected cells tumors, but not normal cells, essential cell immortalization transformation. Immunotherapies being developed target E6/E7 by eliciting antigen-specific immune responses. siRNA technologies modulating expression oncoproteins. Proteasome inhibitors histone deacetylase indirectly interfering with their oncogenic activities. ultimate goal HPV-targeted progression through clinical trials commercialization.
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