Isolation and characterization of five glycerol esters from Wuhan propolis and their potential anti-inflammatory properties.
作者： Haiming Shi , Haisha Yang , Xiaowei Zhang , Yi Sheng , Haiqiu Huang
DOI: 10.1021/JF302601M
关键词:
摘要: Five new glycerol esters including 2-acetyl-1-coumaroyl-3-cinnamoylglycerol (13), (+)-2-acetyl-1-feruloyl-3-cinnamoylglycerol (14), (-)-2-acetyl-1-feruloyl-3-cinnamoylglycerol (15), 2-acetyl-1,3-dicinnamoylglycerol (16), and (-)-2-acetyl-1-(E)-feruloyl-3-(3″(ζ),16″)-dihydroxy-palmitoylglycerol (17) were isolated from methanolic extract of Wuhan propolis. The chemical structures the five compounds confirmed by (1)H (13)C NMR HR-MS spectra. Twelve minor constituents in propolis tentatively identified UPLC-Q-TOF-MS, according to their characteristic UV spectrum, retention times, accurate MS data. anti-inflammatory activities studied lipopolysaccharide (LPS)-stimulated RAW 264.7 mouse macrophage cells. All exhibited remarkable inhibitory effects on interleukin (IL)-1β, IL-6, cyclooxygenase (COX)-2 mRNA expressions at 10 100 μM, suggesting that may serve as a potential functional food ingredient or nutraceutical.
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