Interaction between early life stress and alcohol dependence on neural stress reactivity

摘要: Stress response biologic systems are altered in alcohol-dependent individuals. Early life stress (ELS) is associated with a heightened risk of alcohol dependence, presumably because stress-induced neuroplastic changes. This study was designed to assess the contribution ELS neural participants. Fifteen men abstinent for 3-5 weeks and 15 age- race-matched healthy controls were studied. Anticipatory anxiety induced by conditioned stimulus paired an uncertain physically painful unconditioned stressor. Neural assessed functional magnetic resonance imaging. Childhood Adversity Interview. There significant interaction between group on blood-oxygen-level-dependent (BOLD) amplitude during anticipatory right amygdala bilateral orbitofrontal cortex, posterior putamen insula. Higher scores decreased BOLD alcohol-dependent, but not control, These findings suggest that interacts dependence induce muted cortico-striatal high threat stimuli. Allostatic changes due both excessive use may jointly persistent acute stressors.