Effects of Prestorage Leukoreduction on the Rate of Febrile Nonhemolytic Transfusion Reactions to Red Blood Cells in a Tertiary Care Hospital.

摘要: Background: Febrile nonhemolytic transfusion reactions (FNHTRs) are relatively common complications associated with allogenic transfusion. White blood cells (WBCs or leukocytes) considered to be an important cause of FNHTRs; the rate WBC derived pro‑inflammatory cytokines increase storage due active synthesis by these cells. The removal WBCs before will prevent accumulation during that leads a reduction in number FNHTRs. Aim: We have conducted retrospective analysis comparing FNHTRs prestorage leukoreduced (PrSLR) and non RBCs Subjects Methods: A review all (TRs) reported department over period 2 years from July 2012 June 2014 was done. Patients were stratified date reaction component received then divided into two groups: (1) who allogeneic PrSLR (2) nonleukoreduced RBCs. For RBC units, leukoreduction performed using buffy coat method preparation quadruple bags integral containing Sepacell® Pure RC filters (Fenwal™ France). Results: 37,232 units transfused out which 14149 (38% i.e. is 14149/37232) 23083 (62%) leukoreduced. total 142 (0.38%) TRs time period, 62 (0.17%) classified as In group 124 reported, 55 overall FNHTR 0.24%. pre group, 18 7 0.05% (P ≤ 0.001). This represents significant after institution leukoreduction. Conclusion: implementation has decreased significantly. Cytokines chemokines accumulating cellular products responsible for residual