Exploiting Unique Structural and Functional Properties of Malarial Glycolytic Enzymes for Antimalarial Drug Development

摘要: Metabolic enzymes have been known to carry out a variety of functions besides their normal housekeeping roles as “moonlighting functions.” These functionalities arise from structural changes induced by posttranslational modifications and/or binding interacting proteins. Glycolysis is the sole source energy generation for malaria parasite Plasmodium falciparum, hence potential pathway therapeutic intervention. Crystal structures several P. falciparum glycolytic solved, revealing that they exhibit unique differences respective host enzymes, which could be exploited selective targeting. In addition, these many parasite-specific functions, interest control development and transmission. This review focuses on moonlighting functional features transmission blocking interventions against malaria.