Sustained IL-6/STAT-3 signaling in cholangiocarcinoma cells due to SOCS-3 epigenetic silencing.

作者: Hajime Isomoto , Justin L. Mott , Shogo Kobayashi , Nathan W. Werneburg , Steve F. Bronk

DOI: 10.1053/J.GASTRO.2006.10.037

关键词:

摘要: … To confirm that the observations with DAC were due to demethylation of the socs-3 promoter, methylation specific PCR was performed. Indeed, DAC treatment converted the methylated …

参考文章(57)
A. Knuth, H. Gabbert, W. Dippold, O. Klein, W. Sachsse, D. Bitter-Suermann, W. Prellwitz, K.H. Meyer zum Büschenfelde, Biliary adenocarcinoma. Characterisation of three new human tumor cell lines. Journal of Hepatology. ,vol. 1, pp. 579- 596 ,(1985) , 10.1016/S0168-8278(85)80002-7
Michael Hörtner, Ulrich Nielsch, Lorenz M. Mayr, Peter C. Heinrich, Serge Haan, A new high affinity binding site for suppressor of cytokine signaling-3 on the erythropoietin receptor FEBS Journal. ,vol. 269, pp. 2516- 2526 ,(2002) , 10.1046/J.1432-1033.2002.02916.X
Nathan W. Werneburg, Ali E. Canbay, Jung Hwan Yoon, Scott H. Kaufmann, Steven W. Edwards, Cahit Akgul, Hajime Higuchi, Gregory J. Gores, Bile acids inhibit Mcl-1 protein turnover via an epidermal growth factor receptor/Raf-1-dependent mechanism. Cancer Research. ,vol. 62, pp. 6500- 6505 ,(2002)
Peter A Jones, Daiya Takai, The CpG island searcher: a new WWW resource. in Silico Biology. ,vol. 3, pp. 235- 240 ,(2003)
Lisa M. Coussens, Zena Werb, Inflammation and cancer Nature. ,vol. 420, pp. 860- 867 ,(2002) , 10.1038/NATURE01322
Yukihiro Shimizu, Anthony J. Demetris, Susanne M. Gollin, Patrick D. Storto, H. Melanic Bedford, Silvio Altarac, Shunzaburo Iwatsuki, Ronald B. Herberman, Theresa L. Whiteside, Two new human cholangiocarcinoma cell lines and their cytogenetics and responses to growth factors, hormones, cytokines or immunologic effector cells International Journal of Cancer. ,vol. 52, pp. 252- 260 ,(1992) , 10.1002/IJC.2910520217
David R. Hodge, Elaine M. Hurt, William L. Farrar, The role of IL-6 and STAT3 in inflammation and cancer European Journal of Cancer. ,vol. 41, pp. 2502- 2512 ,(2005) , 10.1016/J.EJCA.2005.08.016
Roland Lang, Anne-Laure Pauleau, Evan Parganas, Yutaka Takahashi, Jörg Mages, James N Ihle, Robert Rutschman, Peter J Murray, SOCS3 regulates the plasticity of gp130 signaling Nature Immunology. ,vol. 4, pp. 546- 550 ,(2003) , 10.1038/NI932
David R. Hodge, Benjamin Peng, James C. Cherry, Elaine M. Hurt, Stephen D. Fox, James A. Kelley, David J. Munroe, William L. Farrar, Interleukin 6 Supports the Maintenance of p53 Tumor Suppressor Gene Promoter Methylation Cancer Research. ,vol. 65, pp. 4673- 4682 ,(2005) , 10.1158/0008-5472.CAN-04-3589
G Gores, Cholangiocarcinoma: current concepts and insights. Hepatology. ,vol. 37, pp. 961- 969 ,(2003) , 10.1053/JHEP.2003.50200