The role of TNF and its receptors in Alzheimer’s disease
作者： R Perry
DOI: 10.1016/S0197-4580(01)00291-3
关键词:
摘要: Tumor necrosis factor (TNF) is an important proinflammatory cytokine that upregulated in Alzheimer disease (AD) patients and involved with AD genes. Several TNF promoter polymorphisms increase expression are associated inflammatory infectious diseases. We previously reported results detected a region near the gene. Using family-based association tests we also between haplotype sibling-pair families, significant mean age of onset for group African-American carrying this same haplotype. Previous reports have shown chromosome 1p 12p regions linked to late-onset AD. These two harbor receptors (TNFR) 2 1, respectively, binding them mediates biological effects TNF. found asssociation TNFR2 exon 6 polymorphism families no individuals possessing APOE E4E4 genotype under dominant model. three TNFR1 gene provide further evidence involvement pathogenesis
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