Antibiotic resistance: it’s bad, but why isn’t it worse?

作者: Nicholas Waglechner , Gerard D Wright , None

DOI: 10.1186/S12915-017-0423-1

关键词:

摘要: Antibiotic natural products are ancient and so is resistance. Consequently, environmental bacteria harbor numerous varied antibiotic resistance elements. Nevertheless, despite long histories of production exposure, not resistant to all known antibiotics. This means that there barriers the acquisition a complete armamentarium. The sources, distribution, movement mechanisms in different microbes bacterial populations mosaic features act as slow this movement, thus moderating emergence pan-resistance. highly relevant understanding pathogenic can inform better management practices influence new drug discovery.

参考文章(46)
B J Weigel, S G Burgett, V J Chen, P L Skatrud, C A Frolik, S W Queener, T D Ingolia, Cloning and expression in Escherichia coli of isopenicillin N synthetase genes from Streptomyces lipmanii and Aspergillus nidulans. Journal of Bacteriology. ,vol. 170, pp. 3817- 3826 ,(1988) , 10.1128/JB.170.9.3817-3826.1988
Alejandro Caro-Quintero, Konstantinos T Konstantinidis, Inter-phylum HGT has shaped the metabolism of many mesophilic and anaerobic bacteria The ISME Journal. ,vol. 9, pp. 958- 967 ,(2015) , 10.1038/ISMEJ.2014.193
Lian N. Olsthoorn-Tieleman, Robert-Jan T. S. Palstra, Gilles P. van Wezel, Mervyn J. Bibb, Cornelis W. A. Pleij, Elongation Factor Tu3 (EF-Tu3) from the Kirromycin Producer Streptomyces ramocissimus Is Resistant to Three Classes of EF-Tu-Specific Inhibitors Journal of Bacteriology. ,vol. 189, pp. 3581- 3590 ,(2007) , 10.1128/JB.01810-06
N. Ziemert, A. Lechner, M. Wietz, N. Millan-Aguinaga, K. L. Chavarria, P. R. Jensen, Diversity and evolution of secondary metabolism in the marine actinomycete genus Salinispora Proceedings of the National Academy of Sciences of the United States of America. ,vol. 111, ,(2014) , 10.1073/PNAS.1324161111
E.-B. Goh, G. Yim, W. Tsui, J. McClure, M. G. Surette, J. Davies, Transcriptional modulation of bacterial gene expression by subinhibitory concentrations of antibiotics. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 99, pp. 17025- 17030 ,(2002) , 10.1073/PNAS.252607699
Kirsten I Bos, Verena J Schuenemann, G Brian Golding, Hernán A Burbano, Nicholas Waglechner, Brian K Coombes, Joseph B McPhee, Sharon N DeWitte, Matthias Meyer, Sarah Schmedes, James Wood, David JD Earn, D Ann Herring, Peter Bauer, Hendrik N Poinar, Johannes Krause, None, A draft genome of Yersinia pestis from victims of the Black Death Nature. ,vol. 478, pp. 506- 510 ,(2011) , 10.1038/NATURE10549
Jean-Marie Pagès, Chloë E. James, Mathias Winterhalter, The porin and the permeating antibiotic: a selective diffusion barrier in Gram-negative bacteria Nature Reviews Microbiology. ,vol. 6, pp. 893- 903 ,(2008) , 10.1038/NRMICRO1994
J. F. Linares, I. Gustafsson, F. Baquero, J. L. Martinez, Antibiotics as intermicrobial signaling agents instead of weapons Proceedings of the National Academy of Sciences of the United States of America. ,vol. 103, pp. 19484- 19489 ,(2006) , 10.1073/PNAS.0608949103
Kevin J. Forsberg, Sanket Patel, Molly K. Gibson, Christian L. Lauber, Rob Knight, Noah Fierer, Gautam Dantas, Bacterial phylogeny structures soil resistomes across habitats Nature. ,vol. 509, pp. 612- 616 ,(2014) , 10.1038/NATURE13377