Commentary: Regulating proNGF Action: Multiple Targets for Therapeutic Intervention

摘要: Neurotrophins are initially synthesized as precursor forms that cleaved to release C-terminal mature bind Trk receptors initiate survival and differentiative responses. Recent studies suggest the form of NGF (proNGF) acts a distinct ligand by binding receptor complex p75 sortilin cell death. Induction proNGF has been observed in multiple pathological states injury models central nervous system, blockade proNGF/p75 interaction is efficacious limiting neuronal apoptosis. Multiple strategies may act limit action considered potential therapeutic targets for future development.