Arrhythmogenic substrate for atrial fibrillation: Insights from an integrative computational model of pulmonary veins
作者： Bruce H. Smaill , Oleg V. Aslanidi , Henggui Zhang , Jichao Zhao , Michael A. Colman
DOI: 10.1109/EMBC.2012.6345906
关键词:
摘要: Mechanisms underlying the genesis of re-entrant substrate for atrial fibrillation (AF) in pulmonary veins (PVs) and left atrium (LA) are not well understood. We develop a biophysically detailed computational model PVs surrounding LA tissue. The integrates canine PV single cell electrophysiology with respective 3D tissue geometry fiber orientation reconstructed from micro-CT data. simulations demonstrate that combination anisotropy electrical heterogeneity between causes break-down normal excitation wave-fronts. This leads to generation high-frequency source near sleeves. Evidence such sources have been seen clinically AF patients. In summary, our modeling results provide new insights into arrhythmogenic mechanisms waves AF.
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bristol.ac.uk参考文章(22)
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