A novel computational sheep atria model for the study of atrial fibrillation

摘要: Sheep is an animal model often used for experimental studies into the underlying mechanisms of cardiac arrhythmias. Previous have shown that biophysically detailed computer models heart provide a powerful alternative to underpinning such mechanisms. In this study we developed family mathematical electrical action potentials various sheep atrial cell types. We also 3D anatomical structure atria. By incorporating single structure, novel computational atria has been reconstructed. This was then investigate by which rapid focal activity in pulmonary veins can transit fibrillation. It found anisotropic property arising from fibre plays important role facilitating fibrillatory excitation waves.