Atrial remodeling in an ovine model of anthracycline-induced nonischemic cardiomyopathy: remodeling of the same sort.

摘要: Atrial Remodeling in Doxorubicin Cardiomyopathy. Introduction: All preclinical studies of atrial remodeling heart failure (HF) have been confined to a single model rapid ventricular pacing. To evaluate whether the changes were specific or represented an end result HF, this study aimed characterize ovine doxorubicin-induced cardiomyopathy. Methods and Results: Fourteen sheep, 7 with cardiomyopathy induced by repeated intracoronary doxorubicin infusions controls, studied. The development HF was monitored cardiac imaging hemodynamic parameters. Open chest electrophysiological performed using custom-made 128-electrode epicardial plaque assessing effective refractory period (ERP) conduction velocity. tissues harvested for structural analysis. group had demonstrable moderate global (left ejection fraction [LVEF]: 37.1 vs 46.4%; P = 0.003) showed following compared controls: left dilatation (P 0.02) dysfunction 0.005); longer P-wave duration < 0.05); higher ERP at all cycle lengths ≤ 0.002) locations 0.001); slower velocity increased heterogeneity index fibrosis (right [RA]: 5.9 ± 2.6 2.8 0.9%; 0.0001, [LA]: 3.7 2.2 2.4 1.1%; 0.002), fibrillation (AF) episodes (16 22 2 3 seconds; 0.04). Conclusion: In there significant characterized enlargement/dysfunction, fibrosis, slowed/heterogeneous conduction, refractoriness associated more sustained AF. These findings appear “same sort” previous models implicating final common substrate leading AF HF. (J Cardiovasc Electrophysiol, Vol. 22, pp. 175-182, February 2011)