Gamma-Hydroxybutyrate (Sodium Oxybate): From the Initial Synthesis to the Treatment of Narcolepsy–Cataplexy and Beyond

摘要: Laborit synthesized GHB in the 1960s hoping t would be a precursor for gamma-aminobutyric acid. He found it had unique pharmacological and metabolic effects. was later used totreat sleep-related disorders. In depression could induce sleep-onset REM sleep even paralysis. narcolepsyit improved night quality reduced daytime sleepiness andcataplexy without development of tolerance or significant side Later reports have shown positive clinical effects Parkinson's disease, chronic fatigue syndrome fibromyalgia.