ZHX1 Promotes the Proliferation, Migration and Invasion of Cholangiocarcinoma Cells.
作者： Ryuk-Jun Kwon , Myoung-Eun Han , Ji-young Kim , Liangwen Liu , Yun-Hak Kim
DOI: 10.1371/JOURNAL.PONE.0165516
关键词:
摘要: Zinc-fingers and homeoboxes 1 (ZHX1) is a transcription repressor that has been associated with the progressions of hepatocellular carcinoma, gastric cancer, breast cancer. However, functional roles ZHX1 in cholangiocarcinoma (CCA) have not determined. We investigated expression during proliferation, migration, invasion CCA cells. In silico analysis immunohistochemical studies showed amplification overexpression tissues. Furthermore, knockdown using specific siRNAs decreased cell invasion, whereas promoted all three characteristics. addition, results suggested EGR1 might partially mediate effect on proliferation Taken together, these show promotes present as potential target for treatment CCA.
harvard.edu
paperity.org
core.ac.uk 参考文章(33)
Irene Pierantonelli, Marco Marzioni, Luca Maroni, Jesus M. Banales, Antonio Benedetti, The significance of genetics for cholangiocarcinoma development. Annals of Translational Medicine. ,vol. 1, pp. 28- 28 ,(2013) , 10.3978/J.ISSN.2305-5839.2012.10.04
Charles R. Thomas, Clifton David Fuller, Biliary Tract and Gallbladder Cancer: Diagnosis and Therapy ,(2008)
Shuliang Chen, Xiao Yu, Quan Lei, Lixin Ma, Deyin Guo, None, The sumoylation of zinc‐fingers and homeoboxes 1 (ZHX1) by ubc9 regulates its stability and transcriptional repression activity Journal of Cellular Biochemistry. ,vol. 114, pp. 2323- 2333 ,(2013) , 10.1002/JCB.24579
Ying Chen, Zhanshan Cha, Wenzheng Fang, Baohua Qian, Wenlong Yu, Wenfeng Li, Guanzhen Yu, Yong Gao, The prognostic potential and oncogenic effects of PRR11 expression in hilar cholangiocarcinoma Oncotarget. ,vol. 6, pp. 20419- 20433 ,(2015) , 10.18632/ONCOTARGET.3983
J-C Cheng, H-M Chang, P C K Leung, Egr-1 mediates epidermal growth factor-induced downregulation of E-cadherin expression via Slug in human ovarian cancer cells. Oncogene. ,vol. 32, pp. 1041- 1049 ,(2013) , 10.1038/ONC.2012.127
Sung-Hak Kim, Jinah Park, Moon-Chang Choi, Hwang-Phill Kim, Jung-Hyun Park, Yeonjoo Jung, Ju-Hee Lee, Do-Youn Oh, Seock-Ah Im, Yung-Jue Bang, Tae-You Kim, Zinc-fingers and homeoboxes 1 (ZHX1) binds DNA methyltransferase (DNMT) 3B to enhance DNMT3B-mediated transcriptional repression. Biochemical and Biophysical Research Communications. ,vol. 355, pp. 318- 323 ,(2007) , 10.1016/J.BBRC.2007.01.187
Sirinapa Sribenja, Kanlayanee Sawanyawisuth, Ratthaphol Kraiklang, Chaisiri Wongkham, Kulthida Vaeteewoottacharn, Sumalee Obchoei, Qizhi Yao, Sopit Wongkham, Changyi Chen, Suppression of thymosin β10 increases cell migration and metastasis of cholangiocarcinoma BMC Cancer. ,vol. 13, pp. 430- 430 ,(2013) , 10.1186/1471-2407-13-430
Kazuya Yamada, Richard L. Printz, Haruhiko Osawa, Daryl K. Granner, Human ZHX1: cloning, chromosomal location, and interaction with transcription factor NF-Y. Biochemical and Biophysical Research Communications. ,vol. 261, pp. 614- 621 ,(1999) , 10.1006/BBRC.1999.1087
Hasaya Dokduang, Sirinun Juntana, Anchalee Techasen, Nisana Namwat, Puangrat Yongvanit, Narong Khuntikeo, Gregory J. Riggins, Watcharin Loilome, Survey of activated kinase proteins reveals potential targets for cholangiocarcinoma treatment Tumor Biology. ,vol. 34, pp. 3519- 3528 ,(2013) , 10.1007/S13277-013-0930-9
Matthew J. Olnes, Rodrigo Erlich, A Review and Update on Cholangiocarcinoma Oncology. ,vol. 66, pp. 167- 179 ,(2004) , 10.1159/000077991