Fat / Hippo pathway regulates the progress of neural differentiation signaling in the Drosophila optic lobe

摘要: A large number of neural and glial cell species differentiate from neuronal precursor cells during nervous system development. Two types Drosophila optic lobe neurons, lamina medulla are derived the neuroepithelial (NE) outer anlagen. During larval development, epidermal growth factor receptor (EGFR)/Ras signaling sweeps NE field medial edge drives neuroblast (NB) formation. This signal transient expression a proneural gene, lethal scute, we refer to its array as “proneural wave,” it is marker EGFR/Ras front. In this study, show that atypical cadherin Fat downstream Hippo pathways regulate transduction along and, thus, ensure progress NB differentiation. Fat/Hippo pathway mutation also disrupts pattern formation structure, which associated with regulation neurogenesis. candidate for ligand, Dachsous expressed in posterior lobe, was observed cause similar phenotype fat mutation, although regionally restricted manner. We functions ligand genetically interacts lobe. These findings provide new insights into function pathway, regulates ordered progression neurogenesis complex system.