A Challenge of Numbers and Diversity: Neurogenesis in the Drosophila Optic Lobe

摘要: AbstractThe brain areas that endow insects with the ability to see consist of remarkably complex neural circuits. Reiterated arrays many diverse neuron subtypes are assembled into modular yet coherent functional retinotopic maps. Tremendous progress in developing genetic tools and cellular markers over past years advanced our understanding mechanisms control stepwise production differentiation neurons visual system Drosophila melanogaster. The postembryonic optic lobe utilizes at least two modes neurogenesis distinct from other parts fly central nervous system. In first ganglion, lamina, neuroepithelial cells give rise precursor cells, whose proliferation depend on anterograde signals photoreceptor axons. second medulla, coordinated activity four signaling pathways orchestrates gradual conversion neuroblasts, while a specific cascade te...