Ancestral benzo[a]pyrene exposure affects bone integrity in F3 adult fish ( Oryzias latipes )
作者： Frauke Seemann , Chang-Bum Jeong , Ge Zhang , Miles Teng Wan , Baosheng Guo
DOI: 10.1016/J.AQUATOX.2016.12.018
关键词:
摘要: Benzo[a]pyrene (BaP) at an environmentally relevant concentration (1μg/L) has previously been shown to affect bone development in a transgenerational manner F3 medaka (Oryzias latipes) larvae (17dph). Here, we provide novel histomorphometric data demonstrating that the impaired formation early life stage is not recoverable and can result persistent impairment of metabolism adult fish. A decrease thickness occurrence microcracks ancestrally BaP-treated male fish (F3) were revealed by MicroCt measurement histopathological analysis. The expression twenty conserved miRNAs screened their relative (in ancestral BaP treatment vs control fish) determined quantitative real-time PCR. Attempt was made link miRNA with potential target mRNA medaka. Five functional pairs mRNA/miRNA identified (Osx/miR-214, Col2a1b/miR-29b, Runx2/miR-204, Sox9b/miR-199a-3p, APC/miR-27b). Unique knowledge bone-related response BaP-exposure generation presented. From ecological risk assessment perspective, needs be regarded as skeletal toxicant which exerts far-reaching impact on survival fitness. Given underlying mechanisms cartilage/bone are between mammals, results may also shed light effect disorders mammals/humans.
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