Azotobacter vinelandii Ribonucleic Acid Polymerase VIII. PYROPHOSPHATE EXCHANGE
作者： Joseph S. Krakow , E. Fronk
DOI: 10.1016/S0021-9258(18)63570-7
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摘要: Abstract RNA polymerase directed by d(A-T) carries out an active exchange of 32PPi into UTP in the presence catalytic amounts ATP. In reactions d(I-C), CTP is absolutely dependent on GTP. d(A-T)-directed 32PP-UTP reaction, ATP can be replaced (with varying efficiency) adenosine tetraphosphate, ADP, 5'-AMP and AMP 5'-morpholidate, but not 2',3'-AMP or cyclic 3',5'-AMP. Only UTP, UDP dUTP, will accept 32PP reaction. A model for proposed where initiating purine triphosphate binds to product terminus site pyrimidine engaging PPi substrate site. result a polymerization step followed pyrophosphorolysis prior translocation.
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