Endothelin stimulates prostaglandin endoperoxide synthase-2 mRNA expression and protein synthesis through a tyrosine kinase-signaling pathway in rat mesangial cells.
作者： E. Coroneos , M. Kester , P.J. Thomas , M.J. Dunn
DOI: 10.1016/S0021-9258(17)31684-8
关键词:
摘要: We evaluated the role of endothelin-1 (ET-1), a vasoconstrictor peptide, to regulate prostaglandin endoperoxide synthase (PGHS)-1 and -2 gene expression protein synthesis in cultured rat mesangial cells (MC). ET-1 induced mRNA for PGHS-2 but not PGHS-1 also stimulated accumulation MC. induction was accompanied by sustained enhancement enzymatic activity assessed conversion arachidonic acid E2. The ET-1-stimulated reduced with tyrosine kinase C inhibitors or C-depleted cells. Both dexamethasone heparin ET-1-activated formation. conclude that MC, induces through kinase-dependent pathway.
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