Calculations of intracapillary oxygen tension distributions in muscle

摘要: Characterizing the resistances to O2 transport from erythrocyte mitochondrion is important understanding potential limitations. A mathematical model developed accurately determine eAects of spacing (hematocrit), velocity, and capillary radius on mass transfer coeAcient. Parameters hamster cheek pouch retractor muscle are used in calculations, since significant amounts experimental physiological data modeling available for this muscle. Capillary hematocrit was found have a large eAect PO2 distribution intracapillary coeAcient per unit area, kcap, increased by factor 3.7 lowest (Ha 0:25) highest 0:55) hematocrits considered. Erythrocyte velocity had relatively minor eAect, with only 2.7% increase as 5 25 times observed resting The varied up two standard deviations measurements, resulting variations kcap that <15% at reference case. magnitude these changes increases hematocrit. An equation approximate dependence use simulations network. ” 2000 Elsevier Science Inc. All rights reserved.