Combating pathogens with Cs2.5H0.5PW12O40 nanoparticles: a new proton-regulated antimicrobial agent
作者： Roger Honorato Piva , Marina Campos Rocha , Diógenes Honorato Piva , Oscar Rubem Klegues Montedo , Hidetake Imasato
DOI: 10.1039/C7TB02763J
关键词:
摘要: The transfer of pathogens from contaminated surfaces to patients is one the main causes health care-associated infections (HCAIs). Cases HCAIs due multidrug-resistant organisms have been growing worldwide, whereas inorganic nano-antimicrobials are valuable today for prevention and control HCAIs. Here, we present a cesium salt phosphotungstic heteropolyacid (Cs2.5H0.5PW12O40) as promising nanomaterial use in antimicrobial product technologies. This water-insoluble Keggin exhibits broad biocide spectrum against Gram-positive Gram-negative bacteria, yeasts, filamentous fungi even under dark conditions. Cs2.5H0.5PW12O40 nanoparticles (NPs) act proton-regulated whose activity mediated on release hydronium ions (H3O+), yielding an situ acidic pH several units below those tolerable by most fungal bacterial nosocomial pathogens.
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