Update on cystatin C: new insights into the importance of mild kidney dysfunction.

作者: Michael G Shlipak , Melanie L Praught , Mark J Sarnak

DOI: 10.1097/01.MNH.0000222694.07336.92

关键词:

摘要: Purpose of review Using cystatin C, a novel serum marker kidney function, several studies have shown that mild dysfunction is associated with increased risk for cardiovascular disease and mortality. Studies questioned, however, whether C predominantly measure function. This summarizes the research literature on C. Recent findings One longitudinal study in patients diabetes found to approximate glomerular filtration rate measures over 4 years much better than creatinine. cohorts be linearly mortality, heart failure risk, whereas creatinine predicted only subjects worst study, age, male sex, height weight, smoking, higher C-reactive protein levels were after adjustment clearance, which may suggest nonrenal influences concentrations. Summary Cystatin appears capture association death. Future needs evaluate will an important role clinical medicine.

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