DNA Damage Response Assessments in Human Tumor Samples Provide Functional Biomarkers of Radiosensitivity.

摘要: Predictive biomarkers are urgently needed for individualization of radiation therapy and treatment with radiosensitizing anticancer agents. Genomic profiling human cancers provides us unprecedented insight into the mutational landscape genes directly or indirectly involved in response to radiation-induced DNA damage. However, what extent this wealth structural information about cancer genome produces sensitivity remains be seen. Investigators increasingly studying subnuclear accumulation (ie, foci) proteins damage (DDR), such as gamma-H2AX, 53BP1, RAD51, a surrogate sensitivity. Recent findings from preclinical studies have demonstrated predictive potential DDR foci by correlating clinically relevant end points tumor control probability. Therefore, investigations responses moving cells tissues patients, which is major focus review. The advantage using functional that they can detect alterations repair due various mechanisms. Moreover, provide global measurement network function without needing know identities all components, many remain unknown. Foci assays thus expected yield may complement supersede genomic information, thereby giving oncologists unique opportunities individualize treatments near future.