Mitochondrial heterogeneity in the brain at the cellular level

摘要: Classically, compartmentation of glutamate metabolism in the brain is associated with fact that neurons and glia exhibit distinct differences regard to this amino acid. The recent use 13C-labeled compounds study conjunction availability cell type-specific tissue culture modes has led notion such may even be present individual types, as well glia. To better understand explain this, it proposed mitochondrial heterogeneity exist resulting tricarboxylic acid cycles different properties regarding cycling rates ratio coupling biosynthesis, primarily involving aspartate. These hypotheses are evaluated light current knowledge about structure function.