Immunological activities of cationic methylan derivatives

摘要: Methylan polysaccharide was aminated to add dialkylaminoethyl and free amino groups at hydroxyl sites in the methylan backbone, these derivatives were quaternized produce pH-independent cationic polyelectrolytes. The immunological activities of resulting investigated. Diethylaminoethyl (DEAE)-methylan inhibited classical pathway complement system a dose-dependent way. Quaternized DEAE-methylan exhibited highest anticomplementary among all derivatives. Anticomplementary increased significantly as charge via aminoderivatization followed by quaternization, indicating that there is an electrostatic interaction between negatively charged functional residues on cell.