Phenotypic analysis of lymphocytes infiltrating human cardiac allografts during acute rejection and the development of graft vascular disease
作者： Nicole M. van Besouw , Aggie H. M. M. Balk , Bas Mochtar , Lenard M. B. Vaessen , Willem Weimar
DOI: 10.1007/978-3-662-00818-8_60
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摘要: Acute rejection (AR) and graft vascular disease (GDV) are processes mediated, at least in part, by cellular processes. Therefore, we cultured graft-infiltrating lymphocytes (GIL) from endomyocardial biopsies (EMB) taken during the first year after transplantation, determined their phenotypic composition, correlated it to AR GVD. We observed more often GIL growth EMB with than non-rejection (P = 0.02), but no difference was found between patients without GVD 1 transplantation. CD4 + cells were always numerous CD8 cells, composition nor derived or signs of In conclusion, is cell EMB, development not associated AR, composition.
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