Hypomagnesaemia and its potential impact on thiamine utilisation in patients with alcohol misuse at the Alice Springs Hospital.

摘要: Introduction and Aims Alcohol rapidly reduces thiamine among alcohol-dependent individuals. Poor diet alcohol's impact on absorption, storage, activation excretion of are thought to be the mechanisms. Previous literature identifies magnesium as an important cofactor in utilisation, which might also compromised alcohol dependent patients. The aim was describe status clinical profile for a sample heavy users entering Alice Springs Hospital Northern Territory Australia examine relationship between deficiency, deficiency cognitive functioning. Design Methods Cross-sectional study examining pyrophosphate (TPP) concentrations 62 males 43 females (N = 105; n = 88 Aboriginal, n = 13 non-Indigenous). Cognition assessed using Rowland Universal Dementia Assessment Scale. Results TPP were within or above reference range. Aboriginal patients had significantly lower TPP than non-Indigenous A marginally significant difference found individuals with supplementation recorded previous 20 days compared those without. Mean serum low normal range (i.e. <0.80 mmol L−1) present 48% tested. Serum (but not TPP) correlated positively test scores. Discussion Conclusions Despite increased exposure risk factors Wernicke Korsakoff Syndrome, no patient below High readmission aggressive treatment policies may explain this finding. However, prevalent could contribute impaired utilisation. [Dingwall KM, Delima JF, Gent D, Batey RG. Hypomagnesaemia its potential utilisation misuse at Hospital. Drug Alcohol Rev 2015]