Drug resistance in malaria-a perspective.

摘要: One of the major technical problems facing malaria eradication in certain areas is development drug resistance. Resistance presents difficulties mainly relation to P. falciparum infection. Proguanil and pyrimethamine resistance have seldom been reported other species field chloroquine so far restricted malaria. The distribution multiple South America South-east Asia reviewed figured two maps. The history discussed. main predisposing conditions appear be influx people with low levels immunity into an area continuing transmission, presence there resistant mutant parasites free availability respective antimalarials. It suggested that underlying mechanisms by which strains emerge are essentially same for as folic reductase inhibitors. It moreover may time Africa where, until now, no proved foci such recorded. The weapon against interruption transmission residual spraying but problem this not possible. In these little can done when multiple-resistant present better drugs available. A brief reference made treatment chloroquine-resistant malaria.