Platelet Aggregation Study in Patients With Hemoglobin Eβ Thalassemia in India

摘要: Hemoglobin Eβ thalassemia is a major public health problem in India, especially the state of West Bengal. Various thromboembolic events are common, splenectomized patients. Platelet hyperactivity most likely plays pathogenetic role. To investigate role platelets hypercoagulability, platelet aggregation tests were undertaken present study. Platelet-rich plasma from 30 patients with (15 and 15 nonsplenectomized) studied compared healthy participants. The 4 agonists used adenosine 5-diphosphate, adrenaline (epinephrine), collagen, ristocetin. current study shows both nonsplenectomized had abnormal to normal controls. Splenectomized higher than for all agonists; but statistically significant difference among 2 groups was found only collagen. confirms splenic absence...