Immunoglobulin G (IgG) subclasses and human disease

摘要: The isotypes of IgG, IgG1, IgG2, IgG3, and IgG4 were determined in immunoglobulin preparations the effect on serum levels treated patients. Serum IgG subclass deficiencies recorded different patient groups: (1) IgG2-IgG4 deficiency was associated with IgA deficiency. (2) found patients ataxia telangiectasia. (3) Low IgG2 SLE; one these recurrent pericarditis good results. (4) and/or low IgG3 juvenile diabetes mellitus. (5) Mothers giving birth to severely group B streptococci infected infants showed subclasses indicating that newborns deficient at birth. (6) In a prospective study children otitis media aged 12 32 months significantly reduced considerably high proneness. deficiency, absence antibodies polysaccharide antigen teichoic acid protein alpha-toxin staphylococci demonstrated. Imbalanced pattern increased diseases such as atopic also combination IgE, Henoch-Schonlein vasculitis, idiopathic pulmonary hemosiderosis, chronic mucocutaneous candidiasis, Trichuris trichiura infection.