NMR Spectroscopy in Fragment Based Drug Design
作者： Maurizio Pellecchia
DOI: 10.1007/7355_2009_5
关键词:
摘要: In this chapter we will briefly reiterate critical aspects of solution nuclear magnetic resonance (NMR) spectroscopy approaches and their applications in drug discovery. These are essentially based on a number NMR techniques that have been developed to monitor characterize intermolecular interactions. By way examples, illustrate the unique advantages these offer when employed conjunction with fragment-based ligand design, especially tackling challenging targets.
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