A multiple emulsion method for loading 5‐fluorouracil into a magnetite‐loaded nanocapsule: a physicochemical investigation
作者： Mohsen Ashjari , Sepideh Khoee , Ali Reza Mahdavian
DOI: 10.1002/PI.4154
关键词:
摘要: The preparation of 5-fluorouracil (5-FU) loaded poly(lactic-co-glycolic acid) (PLGA) biodegradable nanocapsules containing magnetite nanoparticles was studied through the modified multiple emulsion solvent evaporation method for magnetically controlled delivery anticancer drugs. morphology and size distribution prepared magnetite/PLGA were investigated by transmission scanning electron microscopy. micrographs showed that magnetic almost spherical in shape their mean diameter nanometer range with a narrow distribution. Fourier transform infrared ultraviolet–visible spectroscopy confirmed incorporation 5-FU molecules into PLGA matrix. content assessed thermogravimetric magnetometry analysis results 35 wt% high responsivity. Magnetometry measurements superparamagnetic properties saturation magnetization 13.7 emu g−1. Such could be considered as an appropriate choice drug targeting. Furthermore, influence some important processing parameters such concentration, initial loading poly(vinyl alcohol) concentration on content, encapsulation efficiency vitro release kinetics optimized. 4–7 60%–80%, respectively, demonstrated at 37 °C buffer solution. All samples exhibited burst stage this its close dependence formulation parameters. Copyright © 2012 Society Chemical Industry
sci-hub.se 参考文章(32)
N. Faisant, J. Akiki, F. Siepmann, J.P. Benoit, J. Siepmann, Effects of the type of release medium on drug release from PLGA-based microparticles: Experiment and theory International Journal of Pharmaceutics. ,vol. 314, pp. 189- 197 ,(2006) , 10.1016/J.IJPHARM.2005.07.030
V. Andreev, B. Kristev, S. Kirov, Other fluorinated pyrimidines in the treatment of solid tumors. Oncology. ,vol. 15, pp. 65- 76 ,(1962) , 10.1159/000224120
JDG Durán, JL Arias, V Gallardo, AV Delgado, None, Magnetic colloids as drug vehicles Journal of Pharmaceutical Sciences. ,vol. 97, pp. 2948- 2983 ,(2008) , 10.1002/JPS.21249
Yaping Li, Manfred Ogris, Jaroslave Pelisek, Wolfgang Röedl, Stability and release characteristics of poly(d,l-lactide-co-glycolide) encapsulated CaPi-DNA coprecipitation International Journal of Pharmaceutics. ,vol. 269, pp. 61- 70 ,(2004) , 10.1016/J.IJPHARM.2003.08.019
Ali Reza Mahdavian, Mohsen Ashjari, Hamid Salehi Mobarakeh, Nanocomposite particles with core-shell morphology. I. Preparation and characterization of Fe3O4–poly(butyl acrylate-styrene) particles via miniemulsion polymerization Journal of Applied Polymer Science. ,vol. 110, pp. 1242- 1249 ,(2008) , 10.1002/APP.28729
Kadriye Ciftci, H Süheyla Kas, A Atilla Hincal, T Meral Ercan, Olgun Güven, Sevket Ruacan, In vitro and in vivo evaluation of PLAGA (50/50) microspheres containing 5-fluorouracil prepared by a solvent evaporation method International Journal of Pharmaceutics. ,vol. 131, pp. 73- 82 ,(1996) , 10.1016/0378-5173(95)04369-1
Scott Goodwin, Caryn Peterson, Carl Hoh, Craig Bittner, Targeting and retention of magnetic targeted carriers (MTCs) enhancing intra-arterial chemotherapy Journal of Magnetism and Magnetic Materials. ,vol. 194, pp. 132- 139 ,(1999) , 10.1016/S0304-8853(98)00584-8
Zhao-Yang Wang, Yao-Ming Zhao, Fang Wang, Jun Wang, Syntheses of poly(lactic acid-co-glycolic acid) serial biodegradable polymer materials via direct melt polycondensation and their characterization Journal of Applied Polymer Science. ,vol. 99, pp. 244- 252 ,(2006) , 10.1002/APP.22468
H Rafati, A.G.A Coombes, J Adler, J Holland, S.S Davis, Protein-loaded poly(dl-lactide-co-glycolide) microparticles for oral administration: formulation, structural and release characteristics Journal of Controlled Release. ,vol. 43, pp. 89- 102 ,(1997) , 10.1016/S0168-3659(96)01475-7
M. Husmann, S. Schenderlein, M. Lück, H. Lindner, P. Kleinebudde, Polymer erosion in PLGA microparticles produced by phase separation method International Journal of Pharmaceutics. ,vol. 242, pp. 277- 280 ,(2002) , 10.1016/S0378-5173(02)00187-4