Sensing the danger in RNA

作者: Marjorie A Robbins , John J Rossi

DOI: 10.1038/NM0305-250

关键词:

摘要: Using siRNA-mediated intereference in a therapeutic setting will require close examination of disturbing side effect: under some circumstances, the technique induces an immune response. Signaling through toll-like receptor is now implicated this response plasmacytoid dendritic cells ( pages 263–270 ).

参考文章(14)
Katalin Karikó, Prakash Bhuyan, John Capodici, Drew Weissman, Small Interfering RNAs Mediate Sequence-Independent Gene Suppression and Induce Immune Activation by Signaling through Toll-Like Receptor 3 The Journal of Immunology. ,vol. 172, pp. 6545- 6549 ,(2004) , 10.4049/JIMMUNOL.172.11.6545
Sayda M. Elbashir, Jens Harborth, Winfried Lendeckel, Abdullah Yalcin, Klaus Weber, Thomas Tuschl, Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells Nature. ,vol. 411, pp. 494- 498 ,(2001) , 10.1038/35078107
Carol A. Sledz, Michelle Holko, Michael J. de Veer, Robert H. Silverman, Bryan R.G. Williams, Activation of the interferon system by short-interfering RNAs Nature Cell Biology. ,vol. 5, pp. 834- 839 ,(2003) , 10.1038/NCB1038
Marco Colonna, Giorgio Trinchieri, Yong-Jun Liu, Plasmacytoid dendritic cells in immunity. Nature Immunology. ,vol. 5, pp. 1219- 1226 ,(2004) , 10.1038/NI1141
Alan J Bridge, Stephanie Pebernard, Annick Ducraux, Anne-Laure Nicoulaz, Richard Iggo, Induction of an interferon response by RNAi vectors in mammalian cells Nature Genetics. ,vol. 34, pp. 263- 264 ,(2003) , 10.1038/NG1173
Luis Dellamary, Simona Bot, Lilin Wang, Adrian Bot, Amy Bloom, Dan Smith, Noncoding RNA danger motifs bridge innate and adaptive immunity and are potent adjuvants for vaccination Journal of Clinical Investigation. ,vol. 110, pp. 1175- 1184 ,(2002) , 10.1172/JCI15536
Gunter Meister, Thomas Tuschl, Mechanisms of gene silencing by double-stranded RNA Nature. ,vol. 431, pp. 343- 349 ,(2004) , 10.1038/NATURE02873
Stephanie Pebernard, Richard D. Iggo, Determinants of interferon-stimulated gene induction by RNAi vectors Differentiation. ,vol. 72, pp. 103- 111 ,(2004) , 10.1111/J.1432-0436.2004.07202001.X
Dong-Ho Kim, Michael Longo, Young Han, Patric Lundberg, Edouard Cantin, John J Rossi, Interferon induction by siRNAs and ssRNAs synthesized by phage polymerase. Nature Biotechnology. ,vol. 22, pp. 321- 325 ,(2004) , 10.1038/NBT940
Mouldy Sioud, Dag R Sørensen, Cationic liposome-mediated delivery of siRNAs in adult mice. Biochemical and Biophysical Research Communications. ,vol. 312, pp. 1220- 1225 ,(2003) , 10.1016/J.BBRC.2003.11.057