Modulatory effects of hormones, drugs, and toxic events on renal organic anion transport.

摘要: The human body is exposed continuously to a wide variety of exogenous compounds, many which are anionic compounds. In addition, products phase II biotransformation reactions negatively charged, viz. glucuronides, sulfate esters, or glutathiones. Renal transport organic anions an important defense mechanism the organism against foreign substances. combination rate uptake and efflux intracellular disposition in proximal tubule determines concentration nephrotoxic potential compound. Modulation anion secretion observed after exposure tubules various hormones, subsequent receptor-mediated response signaled by protein kinases. Transport compounds across basolateral as well luminal membrane modified activation inhibition Protein kinase C reduces mediated transporter 1 (OAT1/Oat1) Oat3 Mrp2-mediated efflux. has been shown inhibit transporting polypeptide (Oatp1) membrane. Additional kinases have implicated regulation transport, role nuclear factors xenobiotic excretion emerging field. physiological transporters may also be influenced factors, such xenobiotics cellular stress. This commentary discusses current knowledge endogenous influences on renal excretion.