Cytoskeletal Regulation of Inflammation and Its Impact on Skin Blistering Disease Epidermolysis Bullosa Acquisita

摘要: Actin remodelling proteins regulate cytoskeletal cell responses and are important in both innate adaptive immunity. These play a major role providing fine balance cascade of biological events that results either protective acute inflammation or chronic leads to host diseases including autoimmune mediated epidermolysis bullosa acquisita (EBA). This review describes the actin cytoskeleton particular protein called Flightless I (Flii) regulating cellular inflammatory its subsequent effect on skin blistering disease EBA. It also outlines potential an antibody based therapy for decreasing Flii expression vivo ameliorate symptoms associated with