Pax6 is required for differentiation of glucagon-producing alpha-cells in mouse pancreas.
作者： Luc St-Onge , Beatriz Sosa-Pineda , Kamal Chowdhury , Ahmed Mansouri , Peter Gruss
DOI: 10.1038/387406A0
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摘要: The functional unit of the endocrine pancreas is islet Langerhans. Islets are nested within exocrine tissue and composed alpha-, beta-, delta- gamma-cells. beta-Cells produce insulin form core islet, whereas gamma-cells arranged at periphery secrete glucagon, somatostatin a pancreatic polypeptide, respectively. Little known about molecular genetic factors regulating lineage different cells. Pancreas development to be abolished in Pdx1-mutant mice Pax4 mutants lack insulin-producing beta-cells. Here we show that paired-box gene Pax6 expressed during early stages mature homozygous mutant glucagon-producing cells, suggesting essential for differentiation alpha-cells. As lacking fail develop any conclude both Pax genes required fate pancreas.
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