Management of the patient with severe refractory rheumatoid arthritis: are the newer treatment options worth considering?

摘要: Rheumatoid arthritis (RA) is a chronic, inflammatory, autoimmune disease leading to joint destruction. It the most common cause of potentially treatable disabilities. The outcome varies from very mild refractory, rapidly progressive type with high mortality rate. In recent years, profound changes in traditional paradigms RA therapy have been introduced. Instead therapeutically approach, aggressive recommended for forms RA. has forced us remodel treatment pyramid, and start new strategies such as saw-tooth or step-down-bridge schedules. last 10 years seen wide acceptance immunosuppressive therapy. These agents hold much promise further A few ago it seemed that we would be unable influence long term RA, but today development drugs techniques increased our chances fighting prospects future are even more promising.