Inhibition of T and B lymphocyte proliferation by rapamycin.

摘要: The immunosuppressive macrolide rapamycin shows marked structural similarity to FK-506, and like FK-506 inhibits the activation of cultured T B lymphocytes at concentrations as low 10(-10) M. However, blocks T-lymphocyte proliferation a much later stage than FK-506. It also human, porcine murine T- B-lymphocyte by all pathways tested, including which are insensitive such interleukin-2 (IL-2)-mediated IL-2-dependent T-cell lines, human peripheral blood phorbol ester anti-CD28 bacterial lipopolysaccharide. Thus these two macrolides that bind competitively same major intracellular receptor protein inhibit quite distinct mechanisms.