The Relationship between TTF-1 Expression and EGFR Mutations in Lung Adenocarcinomas

摘要: Objective To explore the relationship between TTF-1 and EGFR mutations in lung adenocarcinoma tissues to guide clinical treatment timely effectively. Materials Methods we collected 664 tissue samples from patients with histologically confirmed May 2010 April 2013. All tumor were prior administering therapy. was detected byimmunohistochemistry by DNA direct sequencing. Finally, correlation expression presence of analyzed using χ2 test or Fisher’s exact SPSS software version 18.0. Results Of samples, 18 partially positive for (+−), 636 (+) resulting a total rate 98.49% (+,+−)(including partial positive). In only 10 cases negative (−); 1.51%. There 402 without an mutation 262 mutations; 39.46%. The location exon 19 121 18.22%. 21 141 21.23%. Exon 20 sequencing no mutations.A used determine expression.for whole, expression(including positive) has (p<0.001),especially expression,the is significant (p = 0.008). Conclusion In adenocarcinomas, mutations(exon 21). practice, combine mutations, especially can adenocarcinomas.