Les récepteurs à Epidermal Growth Factor (REGF), une nouvelle cible thérapeutique
作者： M Gainet , E Guardiola , A Dufresne , X Pivot
DOI: 10.1016/S1278-3218(03)00019-2
关键词:
摘要: Epidermal Growth Factor receptor (EGFR) are a key factor for the tumoral proliferation and its over expression appears to be powerful prognosis factor. Currently, 2 types of treatments targeting EGFR: monoclonal antibodies anti-EGFR specific inhibitors EGFR tyrosine kinase. The administration these compound alone or in combination with chemotherapy gives some promising results. These targets as anti-cancer therapy had emerged new perspective oncology.
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sci-hub.se 参考文章(11)
Shyh-Min Huang, Paul M. Harari, Epidermal growth factor receptor inhibition in cancer therapy: biology, rationale and preliminary clinical results. Investigational New Drugs. ,vol. 17, pp. 259- 269 ,(1999) , 10.1023/A:1006384521198
J. Baselga, D. Pfister, M.R. Cooper, R. Cohen, B. Burtness, M. Bos, G. D’Andrea, A. Seidman, L. Norton, K. Gunnett, J. Falcey, V. Anderson, H. Waksal, J. Mendelsohn, Phase I studies of anti-epidermal growth factor receptor chimeric antibody C225 alone and in combination with cisplatin Journal of Clinical Oncology. ,vol. 18, pp. 904- 914 ,(2000) , 10.1200/JCO.2000.18.4.904
M C Etienne, X Pivot, J L Formento, R J Bensadoun, P Formento, O Dassonville, M Francoual, G Poissonnet, X Fontana, M Schneider, F Demard, G Milano, A multifactorial approach including tumoural epidermal growth factor receptor, p53, thymidylate synthase and dihydropyrimidine dehydrogenase to predict treatment outcome in head and neck cancer patients receiving 5-fluorouracil British Journal of Cancer. ,vol. 79, pp. 1864- 1869 ,(1999) , 10.1038/SJ.BJC.6690297
Jennifer Rubin Grandis, Mona F. Melhem, William E. Gooding, Roger Day, Valerie A. Holst, Marilyn M. Wagener, Stephanie D. Drenning, David J. Tweardy, Levels of TGF-α and EGFR Protein in Head and Neck Squamous Cell Carcinoma and Patient Survival Journal of the National Cancer Institute. ,vol. 90, pp. 824- 832 ,(1998) , 10.1093/JNCI/90.11.824
J Baselga, The EGFR as a target for anticancer therapy--focus on cetuximab. European Journal of Cancer. ,vol. 37, pp. 16- 22 ,(2001) , 10.1016/S0959-8049(01)00233-7
R.I Nicholson, J.M.W Gee, M.E Harper, EGFR and cancer prognosis. European Journal of Cancer. ,vol. 37, pp. 9- 15 ,(2001) , 10.1016/S0959-8049(01)00231-3
José Santini, Jean-Louis Formento, Mireille Francoual, Gérard Milano, Maurice Schneider, Olivier Dassonville, François Demard, Characterization, quantification, and potential clinical value of the epidermal growth factor receptor in head and neck squamous cell carcinomas. Head and Neck-journal for The Sciences and Specialties of The Head and Neck. ,vol. 13, pp. 132- 139 ,(1991) , 10.1002/HED.2880130209
Fortunato Ciardiello, Paolo Montemaggi, Sabino De Placido, A. Raffaele Bianco, Patrizia Guerrieri, Vincenzo Damiano, Cataldo Bianco, Roberto Bianco, Giampaolo Tortora, John Mendelsohn, Antitumor activity of combined treatment of human cancer cells with ionizing radiation and anti-epidermal growth factor receptor monoclonal antibody C225 plus type I protein kinase A antisense oligonucleotide. Clinical Cancer Research. ,vol. 6, pp. 4343- 4350 ,(2000)
N Magné, X Pivot, R.-J Bensadoun, E Guardiola, G Poissonnet, O Dassonville, M Francoual, J.-L Formento, F Demard, M Schneider, G Milano, The relationship of epidermal growth factor receptor levels to the prognosis of unresectable pharyngeal cancer patients treated by chemo-radiotherapy European Journal of Cancer. ,vol. 37, pp. 2169- 2177 ,(2001) , 10.1016/S0959-8049(01)00280-5
Dong M Shin, Nicholas J Donato, Roman Perez-Soler, Hyung Ju C Shin, Ji Y Wu, Peter Zhang, Kristie Lawhorn, Fadlo R Khuri, Bonnie S Glisson, Jeffrey Myers, Gary Clayman, David Pfister, John Falcey, Harlan Waksal, John Mendelsohn, Waun Ki Hong, None, Epidermal Growth Factor Receptor-targeted Therapy with C225 and Cisplatin in Patients with Head and Neck Cancer Clinical Cancer Research. ,vol. 7, pp. 1204- 1213 ,(2001)