Relative contribution of cardiovascular risk factors and rheumatoid arthritis clinical manifestations to atherosclerosis.

摘要: Objective To estimate the contribution of cardiovascular (CV) risk factors and rheumatoid arthritis (RA) disease manifestations to atherosclerosis in RA. Methods We used high-resolution carotid ultrasound measure intima-media thickness (IMT) plaque 631 RA patients. Using R2 measures from multivariable models, we estimated demographic characteristics (age, sex, ethnic group), CV (diabetes mellitus, hypercholesterolemia, cigarette smoking, hypertension, body mass index, (joint tenderness, swelling, deformity, nodules, erythrocyte sedimentation rate [ESR], C-reactive protein, factor, HLA–DRB1 shared epitope, cumulative glucocorticoid dose) each outcomes. Estimates were obtained full sample, within strata defined by age, group. We tested for interaction between manifestations. Results The factors, IMT varied depending on patients' age stratum. Demographic features explained 11–16% variance, 4%–12%, 1–6%. The greatest occurred youngest group, while that older groups. Results similar. There was a significant number present ESR, suggesting ESR's effect according factors. Conclusion Both established inflammation contribute significantly RA, may modify one another's effects. These findings have implications regarding prevention RA.