A dual role for Ca(2+) in autophagy regulation.
作者： Jean-Paul Decuypere , Geert Bultynck , Jan B. Parys
DOI: 10.1016/J.CECA.2011.04.001
关键词:
摘要: Autophagy is a cellular process responsible for delivery of proteins or organelles to lysosomes. It participates not only in maintaining homeostasis, but also promoting survival during stress situations. now well established that intracellular Ca(2+) one the regulators autophagy. However, this control autophagy by signaling subject two opposite views. On hand, available evidence indicates signals, and mainly inositol 1,4,5-trisphosphate receptors (IP(3)Rs), suppress other elevated cytosolic concentrations ([Ca(2+)](cyt)) were shown promote autophagic process. Here, we will provide critical overview literature discuss both hypotheses. Moreover, suggest model explaining how changes can lead outcomes, depending on state.
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