Measurement and standardization challenges for extracellular vesicle therapeutic delivery vectors.
作者： Bryant C Nelson , Samantha Maragh , Ionita C Ghiran , Jennifer C Jones , Paul C DeRose
关键词:
摘要: Extracellular vesicles (EVs), such as exosomes and microvesicles, are nonreplicating lipid bilayer particles shed by most cell types which have the potential to revolutionize development efficient delivery of clinical therapeutics. This article provides an introduction landscape EV-based vectors under for protein- nucleic acid-based We highlight some pressing measurement standardization challenges that limit translation EVs clinic. Current limiting drug lack of: standardized cell-based platforms production therapeutics; EV reference materials allow researchers/manufacturers validate measurements systems determining molecular composition EVs.
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